Brand Name: SGONEK
Price: $90 -$95/Gram
Place of Origin: Shaanxi, China
Certification: ISO FDA SG COA MSDS
Grade: Food Grade, Medicine Grade
Payment Terms: T/T, Western Union, MoneyGram
Product Name: | Docetaxel | Cas No.: | 125354-16-7 |
Molecular Formula: | C45H55NO15 | Purity: | 99%min |
Brand Name: | SGONEK | Certification: | ISO FDA SG COA MSDS |
Product name: Docetaxel
Active ingredient: Docetaxel
CAS NO.: 114977-28-5
Specification: 99%
Molecular formula: C43H53NO14
Molecular Weight: 807.8792
Characters: white powder
Solubility: Soluble in DMSO at 200 mg/mL; soluble in ethanol at 100 mg/mL; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Docetaxel is one of the taxane type drugs that were originally developed from the yew tree. Docetaxel is a man made drug that was first made from yew tree needles. It is also known by its brand name, Taxotere. It works by stopping thecancer cells from separating into 2 new cells, so it blocks the growth of cancer.
A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent.
Specification |
Method |
||
Product Information |
|||
Product name |
docetaxel |
||
Part of the Plant |
tree |
Conform |
/ |
Country of Origin |
China |
Conform |
/ |
Organoleptic Data |
|||
Appearance |
Fine powder |
Conform |
NLS-QCS-1008 |
Color |
white Powder |
Conform |
GB/T 5492-2008 |
Odor& Taste |
Characteristic |
Conform |
GB/T 5492-2008 |
Process Data |
|||
Solvent(s) Used |
Water and ethyl alcohol |
Conform |
/ |
Extract ration |
99% |
Conform |
|
Content |
docetaxel ≥99% |
99% |
|
Drying Method |
Spray drying |
Conform |
/ |
Excipient |
Maltodextrin |
Conform |
/ |
Physical Characteristics |
|||
Particle Size (80 mesh) |
98.0%pass 80mesh |
Conform |
GB/T 5507-2008 |
Moisture |
<5.0% |
2.8% |
GB/T 14769-1993 |
Ash Content |
<4.0% |
1.4% |
AOAC 942.05, 18th |
Solvent Residue |
Eur. Pharm |
Conform |
NLS-QCS-1007 |
Heavy Metals |
|||
Total Heavy Metals |
<10 ppm |
Conform |
USP <231>, method II |
Arsenic |
<1.0 ppm |
Conform |
AOAC 986.15, 18th |
Lead |
<1.0 ppm |
Conform |
AOAC 986.15, 18th |
Mercury |
<0.5 ppm |
Conform |
AOAC 971.21, 18th |
Pesticide Residue |
|||
666 |
<0.2ppm |
Conform |
GB/T5009.19-1996 |
DDT |
<0.2ppm |
Conform |
GB/T5009.19-1996 |
Microbiology |
|||
Total Plate Count |
<1,000cfu/g |
17cfu/g |
AOAC 990.12, 18th |
Total Yeast & Mold |
<100cfu/g |
3cfu/g |
FDA (BAM) Chapter 18, 8th Ed. |
E. Coli |
Negative |
Negative |
AOAC 997.11, 18th |
Salmonella |
Negative |
Negative |
FDA (BAM) Chapter 5, 8th Ed. |
Docetaxel is approved to be used alone or with other drugs to treat:
Breast cancer that is locally advanced or has metastasized (spread to other parts of the body) and has not gotten better with other chemotherapy. It is also used to treat breast cancer that is node-positive and can be removed bysurgery.Gastric (stomach) cancer that is advanced. It is used in patients who have not been treated with chemotherapy for advanced disease.Non-small cell lung cancer in certain patients whose cancer is locally advanced or has metastasized.Prostate cancer that has metastasized in men whose cancer is hormone-refractory (does not respond tohormone treatment).Squamous cell carcinoma of the head and neck that is locally advanced.
Docetaxel is also being studied in the treatment of other types of cancer.