Brand Name: SGONEK
Price: $10 -$200/Kilogram
Place of Origin: Shaanxi, China
Certification: ISO FDA SG COA MSDS
Grade: Cosmetic Grade, Feed Grade, Food Grade, Medicine Grade,
Payment Terms: T/T, Western Union, MoneyGram
| Product Name: | Gramicidin | Cas No.: | 1405-97-6 |
| Molecular Formula: | C60H92N12O10 | Purity: | 99%min |
| Brand Name: | SGONEK | Certification: | ISO FDA SG COA MSDS |
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English Name
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Gramicidin A
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Appearance
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white powder
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COA
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1405-97-6
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Brand name
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Sgonek |
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Storage
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dry
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Shelf life
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2 Years Proper Storage
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Gramicidin from Bacillus aneurinolyticus (Bacillus brevis) is a linear polypeptide antibiotic with a mixture of gramicidin A, B, C, and D. Gramicidin D is a channel-forming ionophore that flip-flops slowly across the membrane and is a known Pgp substrate and surprisingly was found to inhibit Pgp ATPase activity. This inhibition was reversed by other Pgp substrates suggesting a common drug binding site among MDR substrate-type drugs and chemosensitizers.
Gramicidin A is a lipophilic substance, the two short bacitracin molecules are dimer to the left helix space configuration, constitute a cross-lipid membrane membrane channel to combine and carry a specific cation from the side of the membrane into the channel and then spread to The other side of the membrane, so there is the name of ion antibiotics, so that the cell metabolism can not be normal and inhibited or even death. They have a significant effect on Gram-positive bacteria
The product is white and light yellow crystalline powder. Odorless. Melting point ≥ 229 ℃. Soluble in ethanol, acetic acid, pyridine; slightly soluble in acetone; insoluble in water, ether. Thermal stability, the UV absorption peak of 271,231.5,290.5nm. Not easily digested by protease, but can be acid hydrolysis.
On the Bacillus anthracis, Clostridium perfringens, pneumococcus and golden yellow pus micrococcus and so have a good antibacterial effect.
Take gramicidin A as an example. Because it is a fat-soluble substance, two gramicidins
The molecular dimer is in a left-hand helix spatial configuration, forming a channel across the bilayer lipid membrane membrane to bind and carry specific cations from one side of the membrane into the channel and then diffuse to the other side of the membrane, so there is an ion antibiotic. Said, so that cell metabolism can not be normal and suppressed or even died.
They have a significant effect on gram-positive bacteria. It has good antibacterial activity against Bacillus anthris, Clostridium perfringens, Diplococcus pneumoniae and Micrococcus pyogenes Var. aureus. Only at high concentrations does it have an inhibitory effect on certain gram-negative bacteria.
General ointment formulations for the prevention and treatment of skin purulent disease.
