High Quality skin disease CAS NO.1405-97-6 Peptides Raw Mate

Brand Name: SGONEK

Price: $10 -$200/Kilogram

Place of Origin: Shaanxi, China

Certification: ISO FDA SG COA MSDS

Grade: Cosmetic Grade, Feed Grade, Food Grade, Medicine Grade,

Payment Terms: T/T, Western Union, MoneyGram

Product Name:  Gramicidin Cas No.:  1405-97-6
Molecular Formula:  C60H92N12O10 Purity:  99%min
Brand Name:  SGONEK Certification:  ISO FDA SG COA MSDS

High Quality skin disease CAS NO.1405-97-6 Peptides Raw Mate

 English Name
Gramicidin A 
 white powder 
 Brand name
 Shelf life
2 Years Proper Storage

Gramicidin from Bacillus aneurinolyticus (Bacillus brevis) is a linear polypeptide antibiotic with a mixture of gramicidin A, B, C, and D. Gramicidin D is a channel-forming ionophore that flip-flops slowly across the membrane and is a known Pgp substrate and surprisingly was found to inhibit Pgp ATPase activity. This inhibition was reversed by other Pgp substrates suggesting a common drug binding site among MDR substrate-type drugs and chemosensitizers. 

Items of analysisSpecificationResultsAppearance:White  Crystalline powderWhite  Crystalline powderAssay:98.0-102.0%99.61%Taste:PurePureParticle Size100 meshpassSpecific rotation:+14.50°—+16.50°+15.62°Transmittance:≥95%98.50%Loss on drying:≤4.5%3.1Residue on ignition:≤0.2%0.10%Heavy metals:≤10ppm10ppmArsenic:≤3ppm3ppmPH4.5-6.05.15Other relates impurities:≤2.0%2.00%Organic volatile impurities:Meets  the  requirementMeet the requirement5-benzyl-3.6-dioxo-2-piperazineacetic acid≤1.5%1.50%



Gramicidin A  is a lipophilic substance, the two short bacitracin molecules are dimer to the left helix space configuration, constitute a cross-lipid membrane membrane channel to combine and carry a specific cation from the side of the membrane into the channel and then spread to The other side of the membrane, so there is the name of ion antibiotics, so that the cell metabolism can not be normal and inhibited or even death. They have a significant effect on Gram-positive bacteria

The product is white and light yellow crystalline powder. Odorless. Melting point ≥ 229 ℃. Soluble in ethanol, acetic acid, pyridine; slightly soluble in acetone; insoluble in water, ether. Thermal stability, the UV absorption peak of 271,231.5,290.5nm. Not easily digested by protease, but can be acid hydrolysis. 

On the Bacillus anthracis, Clostridium perfringens, pneumococcus and golden yellow pus micrococcus and so have a good antibacterial effect.  

Take gramicidin A as an example. Because it is a fat-soluble substance, two gramicidins
The molecular dimer is in a left-hand helix spatial configuration, forming a channel across the bilayer lipid membrane membrane to bind and carry specific cations from one side of the membrane into the channel and then diffuse to the other side of the membrane, so there is an ion antibiotic. Said, so that cell metabolism can not be normal and suppressed or even died.
They have a significant effect on gram-positive bacteria. It has good antibacterial activity against Bacillus anthris, Clostridium perfringens, Diplococcus pneumoniae and Micrococcus pyogenes Var. aureus. Only at high concentrations does it have an inhibitory effect on certain gram-negative bacteria.
General ointment formulations for the prevention and treatment of skin purulent disease. 

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