Pharmaceuticals Material and Intermediate Powder Cas 361442-_Xian Sgonek Biological Technology Co.,Ltd

Pharmaceuticals Material and Intermediate Powder Cas 361442-

Product Name	Saxagliptin
CAS No.	361442-04-8
Purity	99%
Appearance	White Powder
Molecular Formula	C18H25N3O2
EINECS No.	/
Description: Glatiramer acetate (also known as Copolymer 1, Cop-1, or Copaxone - as marketed by Teva Pharmaceuticals) is animmunomodulator drug currently used to treat multiple sclerosis. It is a random polymer of four amino acids found inmyelin basic protein, namely glutamic acid, lysine, alanine, and tyrosine, and may work as a decoy for the immune system.

Test	Specifications	Result
Assay Content % by HPLC	Min.98%	99.08%
Appearance	white powder	Complies
Odor	Characteristic	Complies
PH	5.0-7.0	6.09
Clarity of water solution	Transparent, colorless, none suspended matters	Complies
Loss on drying %	MAX 0.5	0.25
Ash %	MAX.0.5	0.38
Melting point	+202.0-212.0°C	Complies
Specific rotation	+174.0-+186.0	+181.0
Hydroquinone	Negative	Complies
Heavy metals PPM	MAX.10	Complies
As AAS Pb Cd	<2ppm <1ppm <1ppm	Complies Complies Complies
Microbiology Total Plate Count Yeast & Mold E.Coli S. Aureus Salmonella	<1000cfu/g <100cfu/g Negative Negative Negative	122 cfu/g 13 cfu/g Complies Complies Complies
Conclusion	Conform with specification

Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor antidiabetic for the treatment of type 2 diabetes. DPP-4 inhibitors are a class of compounds that work by affecting the action of natural hormones in the body called incretins. Incretins decrease blood sugar by increasing consumption of sugar by the body, mainly through increasing insulin production in the pancreas, and by reducing production of sugar by the liver. [Bristol-Myers Squibb Press Release] DPP-4 is a membrane associated peptidase which is found in many tissues, lymphocytes and plasma. DPP-4 has two main mechanisms of action, an enzymatic function and another mechanism where DPP-4 binds adenosine deaminase, which conveys intracellular signals via dimerization when activated.Saxagliptin forms a reversible, histidine-assisted covalent bond between its nitrile group and the S630 hydroxyl oxygen on DPP-4. The inhibition of DPP-4 increases levels active of glucagon like peptide 1 (GLP-1), which inhibits glucagon production from pancreatic alpha cells and increases production of insulin from pancreatic beta cells.

Saxagliptin is a potent Dipeptidyl Peptidase-4 (DPP-4) inhibitor that can increase endogenous levels by selectively inhibiting DPP-4 Glucagon-like Peptide-1 (GLP-1) and Glucose-dependent Insulinotropic Peptide (GIP) levels regulate blood glucose.

Product Name:	Saxagliptin	Cas No.:	361442-04-8
Molecular Formula:	C18H25N3O2	Purity:	99%min
Brand Name:	SGONEK	Certification:	ISO FDA SG COA MSDS

Pharmaceuticals Material and Intermediate Powder Cas 361442-

Pharmaceuticals Material and Intermediate Powder Cas 361442-

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