Medicine Grade Powder For HIV-1 or HBV CAS No.143491-57-0 Em

Brand Name: SGONEK

Price: $450 -$700/Kilogram

Place of Origin: Shaanxi, China

Certification: ISO FDA SG COA MSDS

Grade: Pharmaceutcial Grade

Payment Terms: T/T, Western Union, MoneyGram

Product Name:  Emtricitabine Cas No.:  143491-57-0
Molecular Formula:  C8H10FN3O3S Purity:  99%min
Brand Name:  SGONEK Certification:  ISO FDA SG COA MSDS

Medicine Grade Powder For HIV-1 or HBV CAS No.143491-57-0 Em

Product Name  Emtricitabine
CAS No.  143491-57-0
Purity  99%
Appearance  White Crystalline Powder
Molecular Formula  C8H10FN3O3S
EINECS No.  604-363-1

Description: 

Emtricitabine is a New anti-HIV drugs nucleoside reverse transcriptaseinhibitor (NRTI) which has been marketed for the prevention and treatment of HIV infection. It also exhibits clinical activity against the hepatitis B virus (HBV) (not yet approved by FDA).Emtricitabine is a synthetic nucleoside analogue of cytidine.


 

Items Specifications Result
Description White to off-white solid Conforms
Identification HPLC ,IR Conforms
Solubility Soluble in water and ethanol;sparingly soluble in ethyl acetate Conforms
Melting point 177-182℃ 179.5-180.5℃
Loss on drying ≤0.5% 0.40%
Water ≤0.5% 0.12%
Specific optical rotation [a]D20 -29.1±5°(c=2g/100ML methanol) -30.2°
Residue on ignition ≤0.5% 0.10%
Heavy metals ≤20ppm <10ppm
Related substances Any single impurity ≤0.1% 0.01%
Total impurity≤1.0% 0.04%
Enantiometric purity ≥99.5% 99.8
Assay (HPLC) 98.5-101.5% 99.96%
Organic volatile impurities Meet ICH Q3C requirements confirms

 


Emtricitabine is a nucleoside analogue and reverse transcriptase inhibitor used in combination with other agents for treatment and prevention of human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS). 


1. HIV infection
Emtricitabine is indicated in combination with other antiretroviral agents for the treatment of HIV infection in adults. Emtrici-   tabine is commercially available and is approved by the FDA for treatment of HIV infection.
2. HBV infection
Emtricitabine exhibits clinical activity against the hepatitis B virus (HBV), but is not approved by the FDA for the treatment of HBV infection. Among individuals with chronic HBV infection, emtricitabine treatment results in significant histologic, virolo- gic, and biochemical improvement. The safety profile of emtricitabine during treatment is similar to that of a placebo. Emtrici- tabine, like all other FDA approved drugs, cures neither HIV nor HBV infection. In a study involving individuals with HBV    infection, symptoms of infection returned in 23% of emtricitabine-treated individuals who were taken off therapy. In studies    involving individuals with chronic HIV infection, viral replication also resumes when study subjects are taken off therapy. As    with drugs used to treat HIV infection, drugs used to treat HBV infection may have to be used in combination to prevent the evolution of drug resistant strains. The effectiveness of emtricitabine in combination with other anti-HBV drugs has not been  established.

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