Oxytetracycline is a broad spectrum of antibiotics, its antibacterial spectrum, antibacterial principle and application and tetracycline is basically the same. Many Rickettsia, Mycoplasma, Chlamydia, Spirochetes, Amoeba and some Plasmodium are also sensitive to this product. 

Enterococcus is resistant to it. Other such as actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter, Yersinia are sensitive to this product. This product has a certain antibacterial activity against Neisseria gonorrhoeae and meningococcus, but resistant to penicillin Neisseria gonorrhoeae is also resistant to oxytetracycline. 

Over the years due to the wide application of tetracyclines, clinical common pathogens resistant to oxytetracycline serious, including Staphylococcus aureus and other Gram-positive bacteria and most Gram-negative bacilli. 

There is cross-resistance between different varieties of tetracycline antibiotics.  Oxytetracycline mechanism for the drug can specifically with the bacterial ribosome 30S subunit A position of the combination of inhibition of peptide chain growth and the impact of bacterial protein synthesis. This product on intestinal infections, including amoebic dysentery, the effect is slightly stronger than tetracycline. And tetracycline has a close cross-resistance.

Oxytetracycline hydrochloride can be used as a drug for the following diseases:

1. Rickettsia disease, including epidemic typhus, endemic typhus, rocky mountain fever, tsutsugamushi disease and Q fever
2. Mycoplasma infection
3.Chlamydia infection, including parrot fever, sexually transmitted diseases, lymphoid edema, nonspecific urethritis, salpingitis, cervicitis and trachoma
4.return to heat brucellosis
5.Cholera
6.Rabbit fever
7.Plague chancre.

Treatment of brucellosis and plague when combined with aminoglycosides.

As the current common pathogens resistant to oxytetracycline hydrochloride serious, only in the pathogen sensitive to the goods, can be used as a drug: the sensitive strains of Escherichia coli, Enterobacter aeruginosa, , Shigella, Haemophilus influenzae (respiratory tract infection only) and Klebsiella (limited to respiratory and urinary tract infections) and other Gram-negative bacilli infection.
Oxytetracycline should not be used for any type of staphylococcus or hemolytic streptococcal infection.Oxytetracycline can be used for penicillin allergy to tetanus, gas gangrene, yas, syphilis, gonorrhea and leptospirosis as well as actinomycetes, Listeria infection in patients.
Oxytetracycline can be used for acute intestinal amebiasis and moderate to severe acne patients as adjuvant therapy.