High quality pharmaceutical price 5%~99% Gentamicin powder

Brand Name: SGONEK

Price: $40 -$210/Kilogram

Place of Origin: Shaanxi, China

Certification: ISO FDA SG COA MSDS

Grade: FEEd Grade Pharmaceutical Grade

Payment Terms: T/T, Western Union, MoneyGram

Product Name:  Gentamicin Cas No.:  1403-66-3
Molecular Formula:  C21H43N5O7 Purity:  99%min
Brand Name:  SGONEK Certification:  ISO FDA SG COA MSDS

High quality pharmaceutical price 5%~99% Gentamicin powder

Product Name: Gentamicin Powder 

Molecular Formula:C21H43N5O7

CAS No.:1403-66-3

EINECS:215-765-8

Purity:99%

Appearance:White Crystalline powder 

 

 

 What is Gentamicin?

Gentamicin is one of the few thermally stable antibiotics and is therefore widely used in media configurations. 
China's independently developed broad-spectrum antibiotics are one of the great scientific and technological achievements since the founding of New China. 
Gentamicin began to be developed in 1967. Gentamicin was successfully appraised at the end of 1969. Gentamicin was named "Gentamicin,"which means celebrating the Nine Congress and celebrating the greatness of the working class. 
Gentamicin (gentamycin) is extracted from the fermentation broth of actinomycete monosporidium and is a basic compound. 
Gentamicin is a commonly used aminoglycoside antibiotic.Gentamicin is mainly used to treat bacterial infections,especially those caused by gram-negative bacteria.Gentamicin binds to the bacterial ribosome 30s subunit and blocks bacterial protein synthesis.

ITEMS

SPECIFICATION

RESULTS

BP2010 /EP6

Appearance

crystalline powder

Conforms

Melting point

About 205°C

206.4°C~206.7°C

Identification

Meet the requirements

Conforms

Appearance of

solution

Clear, not more intense than Y7

Conforms

PH

2.4~3.0

2.60

Loss on drying

≤0.5%

0.04%

Sulphated ash

≤0.1%

0.01%

Heavy metals

≤20 ppm

<20 ppm

Related substances

≤0.25%

Conforms

Assay

99.0%~101.0%

99.8%

USP32

Identification

Meet the requirements

Conforms

Loss on drying

≤0.5%

0.04%

Residue on ignition

≤0.1%

0.01%

Heavy metals

≤0.003%

<0.003%

Residue solvent - Ethanol

≤0.5%

<0.04%

Chloride

16.9%~17.6%

17.1%

Assay

98.0%~102.0%

100.0%

Conclusion: The product complies with BP2010/USP32/EP6 standard


Gentamycin is an aminoglycoside drug.Its mechanism of action is to act on ribosomes in bacteria,inhibit bacterial protein synthesis,and destroy the integrity of bacterial cell membranes. 
Gentamicin can first pass through the extracellular membrane porin by passive diffusion,then enter the cell through the cell membrane via the transport system,and irreversibly binds to the isolated 30S subunit of the ribosome,resulting in destruction of the A-site, and thus:

1. To prevent the correct localization of ammonia tRNAs in the A-position,especially to interfere with the 
    binding of methionyl-tRNA, thereby interfering with the assembly of functional ribosomes and inhibiting 
    the formation of the 70S initiating complex.

2. Induced mismatch between tRNA and mRNA crypto-triad,causing the 30S subunit of the intact 
    ribosome to misread the genetic code,causing erroneous amino acid insertion into the protein 
    structure,resulting in abnormal,non-functional protein synthesis.

3. Impeding the termination factor from binding to the A position, so that the synthesized peptide chain 
    cannot be released and prevent the 70S intact ribosomes from dissociating.

4. Blocking the depolymerization and assembly of polyribosomes,causing ribosomal depletion in bacteria.
    Gentamicin against Pseudomonas aeruginosa,Proteus (positive and negative),Escherichia coli, 
    Klebsiella, Enterobacter, Serratia, Shigella, Citrobacter Neisseria, Staphylococcus aureus (excluding 
    methicillin-resistant strains) has strong antibacterial activity. 
    Gentamicin is not effective against streptococci (including Streptococcus pyogenes,Streptococcus 
    pneumoniae,Streptococcus faecalis, etc.),anaerobic bacteria (Bacteroides),Mycobacterium 
    tuberculosis,Rickettsia,viruses,and fungi.

1. Applicable to the treatment of sensitive bacteria caused by neonatal sepsis, sepsis.

2. Applicable to the treatment of respiratory tract infections, peritonitis, biliary tract infections caused 
    by sensitive bacteria.

3. Applicable to the treatment of urogenital infections caused by susceptible strains (other than initial 
    treatment of simple urinary tract infections).

4. Applicable to the treatment of skin and soft tissue infections caused by susceptible bacteria,burns and 
    other infections.

5. Oral can be used for bowel infection or preparation before colon surgery

6. Intramuscular injection of clindamycin or metronidazole in combination can be used to reduce the
    incidence of infection after colon surgery.

7. Intrathecal injection can be used as adjuvant therapy for severe central nervous system infection 
    (acute purulent meningitis,ventriculitis)caused by Pseudomonas aeruginosa or Staphylococcus 
    aureus.

8. Gentamicin can also be used to treat listeriosis.

9. Gentamicin eye drops apply to coagulase-negative and positive staphylococci,Pseudomonas 
    aeruginosa and E. coli, K. pneumoniae and other gram-negative bacilli and gonococcal conjunctivitis, 
    keratitis,tears Bladder inflammation,blepharitis,meibomian gland inflammation,etc.

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